“Medicinal Applications of Coordination Chemistry”
نویسندگان
چکیده
منابع مشابه
Medicinal Chemistry of Cannabinoids
The endocannabinoid system comprises the two well characterized Gi/o -protein coupled receptors (cannabinoid receptor 1 (CB1) and CB2), their endogenous lipid ligands, and the enzymes involved in their biosynthesis and biotransformation. Drug discovery efforts relating to the endocannabinoid system have been focused mainly on the two cannabinoid receptors and the two endocannabinoid deactivatin...
متن کاملDrug design, biotechnology and medicinal chemistry: applications to infectious diseases
current drug design strategies are based on the understanding of the physio-pathology of diseases, biochemical pathways and selection of molecular targets. Modernbiotechnological tools have provided valuable information to facilitate the discovery ofnew drug candidates. Medicinal chemistry has a vital role in a variety of processes aimedat the identification of bioactive substan...
متن کاملCoordination chemistry and applications of versatile 4,5-diazafluorene derivatives.
This perspective review will examine the coordination chemistry and applications of metal complexes of 4,5-diazafluorene derivatives. The versatile derivatives of 4,5-diazafluorene can serve multiple roles, and display a number of coordination modes. The ambidentate derivatives with multiple coordination sites can allow for the syntheses of coordination polymers, multimetallic, and macrocyclic ...
متن کاملClick chemistry reactions in medicinal chemistry: applications of the 1,3-dipolar cycloaddition between azides and alkynes.
In recent years, there has been an ever-increasing need for rapid reactions that meet the three main criteria of an ideal synthesis: efficiency, versatility, and selectivity. Such reactions would allow medicinal chemistry to keep pace with the multitude of information derived from modern biological screening techniques. The present review describes one of these reactions, the 1,3-dipolar cycloa...
متن کاملFluorine in medicinal chemistry.
Since its first use in the steroid field in the late 1950s, the use of fluorine in medicinal chemistry has become commonplace, with the small electronegative fluorine atom being a key part of the medicinal chemist's repertoire of substitutions used to modulate all aspects of molecular properties including potency, physical chemistry and pharmacokinetics. This review will highlight the special n...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Platinum Metals Review
سال: 2008
ISSN: 0032-1400,1471-0676
DOI: 10.1595/147106708x259497